Job Description

Subject to applicable law, all prospective hires will be required to demonstrate that they have been fully vaccinated for COVID-19 or intend to be vaccinated for COVID-19 by November 1, 2021, or qualify for a medical or religious accommodation to this vaccination requirement. Hired candidates who are not vaccinated by November 1, 2021, and who have not been approved for a legally-required medical or religious accommodation will be subject to disciplinary action up to and including termination of employment, subject to applicable law.

We are seeking a highly motivated and skilled Scientist with a background in Oncology target identification and validation to join a cross-functional team within Discovery Oncology. Primary responsibilities will include designing and executing experiments in the laboratory to identify and validate novel targets for our early discovery pipeline. An ability to communicate clearly and collaborate effectively with colleagues in the discovery group as well as scientists from different disciplines will be essential.

The specific responsibilities include but are not limited to:

• Perform CRISPR screens to identify novel targets
• Employ genetic perturbation techniques for target validation and mechanism of action studies
• Develop new methods using CRISPR technology to support target discovery and drug discovery efforts
• Ensure data generated is communicated in a concise, easy to understand manner to the appropriate teams and stakeholders
• Collaborate with colleagues from Discovery Oncology, in vivo pharmacology, Genome and Biomarker Sciences, Chemical Biology, and Quantitative Biosciences to develop and integrate enabling technology to identify and validate novel targets

Required Education and Experience:

• The ideal candidate will have a BS/MS degree in the biological sciences, with 1-5 years of experience in the area of cancer biology, molecular biology, or related area.

Required Skills:

• Expertise in mammalian cell culture
• Expertise in CRISPR/Cas9 genetic perturbation with lentivirus and RNP delivery
• Expertise in cell and molecular biology techniques including PCR, qRT-PCR, western blot, flow cytometry, and proliferation/cytotoxicity/apoptosis assays
• Demonstrated ability to work independently to design experiments, interpret data, troubleshoot, and suggest next steps
• Candidate should be a strong team player with excellent oral and written communication skills and with a demonstrated ability to work collaboratively and thrive in a team environment
• Excellent organization and ability to contribute to multiple projects

Preferred Skills:

• Experience performing functional genomics screens
• Experience with cloning and lentivirus generation; overexpression of wildtype and mutant constructs
• Experience with assessment of CRISPR editing efficiency using Sanger sequencing or NGS

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world’s most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers’ Policy – Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

No relocation

VISA Sponsorship:

No

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:

2

Requisition ID:R137128